Includes bibliographical references (p. 303-372) and index
|Statement||by Constantin Bona ; foreword by Noel R. Rose|
|LC Classifications||QR184.5 .B66 2005|
|The Physical Object|
|Pagination||xi, 389 p. :|
|Number of Pages||389|
|ISBN 10||158829319X, 1592598250|
|LC Control Number||2004007841|
Constantin Bona, New Jersey: Published by The Humana Press, , $ (hardback), pp ISBN X Having thoroughly searched our modest special care unit library, I decided that there is most definitely a space on the shelf for this text on neonatal immunity. Whether or not it actually deserves such a resting place is a matter for debate. Neonates have little immunological memory and a developing immune system, which increases their vulnerability to infectious agents. Recent advances in understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of by: During the past 50 years, the field of neonatal immunology has been influenced by such dogmas as “The neonatal age is a window of time when tolerance develops,” and “Neonatal immune cells. ISBN: X OCLC Number: Description: xi, pages: illustrations ; 24 cm. Contents: Structure and function of immune system in vertebrates --Ontogeny and development of cells mediating innate and adaptive immunity --Phenotypic characteristics of neonatal B cells --Molecular characteristics of neonatal B cell repertoire --Genetically programmed temporal ordered.
The ways in which maternal antibodies enhance neonatal immunity includes interference with growth of the pathogen and by facilitating organism removal by a process of opsonisation. The antibody-coated pathogens are also more easily taken up by phagocytes that express Fc receptors which improves antigen presentation to T cells. In addition, maternal antibody-coated antigen is trapped by. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. : Humana Press. This review summarizes the knowledge about the function of the different arms of neonatal immunity, including what is known about neonatal defense against the pathogens mentioned above. More comprehensive reviews are available elsewhere. Additional information about the development of the cellular components of the immune system is provided. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr.
T1 - Neonatal Immunity. AU - Adkins, Rebecca D. PY - /4/ Y1 - /4/ N2 - The nature of neonatal immunity has defied simple definition, as evidenced by the ongoing evolution of our understanding of responses in early life. In the s, neonates were considered to be immunodeficient, incapable of mounting significant responses of any. Neonatal Th1 immunity: imprinted attributes and the inability to withstand re-challenge with antigen. The fact that neonatal primary responses are comprised of both Th1 and Th2 cells but that the secondary responses are biased towards Th2 cells raises intriguing questions as to the fate of the primary Th1 cells and the mechanism underlying their unresponsiveness during recall with Ag [23, 25].Cited by: "Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation."--Jacket. Animals possess the ability (Immunity) to respond to and resist against the invasion of microorganisms thanks to a highly complex and specialized system (Immune System) of organs, tissues and cells devoted to the surveillance, detection, defensive response and elimination of foreign ("non self”), and therefore potentially pathogenic, counteracting this attack, a defensive response.